Tsin, Wen Yeo and Allen C, Cheng and Yuwana, Podin (2023) Precision Medicine for Sepsis Management in Low- and Middle-Income Countries - Melioidosis as a Model? American Journal of Respiratory and Critical Care Medicine. pp. 1-7. ISSN 535-4970 (In Press)
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Abstract
Advances in translational critical care has revealed limitations in the current clinical management of critical illness which is syndrome based (1). Studies evaluating the host response using immunoassays, multi-omics platforms and bioinformatics analysis have identified heterogenous subgroups (subphenotypes) as well as distinct pathogenic features (endotypes) among patients diagnosed with sepsis (2, 3). This has led to the aim of utilizing a precision medicine approach where targeted therapeutic management is based on utilization of assays to identify subphenotypes or clinical correlates of endotypes. This approach has been used in oncology with significant improvement in outcomes by targeting the underlying biological mechanism in individual patients (1).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | heterogenous subgroups (subphenotypes), pathogenic features (endotypes), bacterial infections. |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine Faculties, Institutes, Centres > Institute of Health and Community Medicine |
| Depositing User: | Podin |
| Date Deposited: | 07 Dec 2023 07:28 |
| Last Modified: | 07 Dec 2023 07:28 |
| URI: | http://ir.unimas.my/id/eprint/43577 |
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