Antibody dynamics post-Comirnaty and CoronaVac vaccination in Malaysia

Cheng Siang, Tan and Vaenessa, Noni and Whilemena Upam, Herman Ulok Melina and Ummi Syafqah, Abdorahman and Joseph Niler, Bimbang and Natasya Marliana, Abdul Malik and Mohammad Esa, Hossen and Md Mizanur, Rahman and Lela, Suut and Asri, Said and Claire, Chen and Bego, Sepop and Morni, Abu Samat and John Chee Ming, Chew and Dewi, Mamora and KongTan, Sian (2022) Antibody dynamics post-Comirnaty and CoronaVac vaccination in Malaysia. Scientific Reports, 12. pp. 1-12. ISSN 2045-2322

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Abstract

Several vaccines have been fast-tracked through clinical trials to mitigate the progression of the SARS‑CoV‑2 pandemic. We analyzed sequential blood samples from 314 recipients of Comirnaty and CoronaVac in East Malaysia for the spike-binding IgG (IgG-S), nucleocapsid-binding IgG (IgG-N), spike-binding IgM (IgM-S) and serum vitamin D (VitD). A subset of samples was analyzed for the neutralizing antibodies (Ig-RBD). Results showed that IgG-S due to Comirnaty was significantly higher than CoronaVac. IgM-S was detected in 80.0% Comirnaty and 69.5% CoronaVac recipients, while IgG-N was detected in 58.1% CoronaVac but not in Comirnaty recipients. All IgG-S-positive vaccines possessed detectable Ig-RBD after the second dose but with a weak to moderate correlation. The serum VitD levels did not influence the antibody magnitude in both vaccines. In essence, SARS-CoV-2 vaccination is an IgG-S-dominant event, Comirnaty was more effective than CoronaVac in mounting IgG-S and Ig-RBD responses, independent of the patient’s VitD level.

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