Synthesis and Antibacterial Activities of Aspirin-Chalcone Derivatives

Phang, Sai Foong. (2015) Synthesis and Antibacterial Activities of Aspirin-Chalcone Derivatives. [Final Year Project Report] (Unpublished)

	PDF PHANG SAI FOONG.pdf Download (272kB)
	PDF (Please get the password by email to repository@unimas.my , or call ext: 082-583914/3973/3933) PHANG SAI FOONG full.pdf Restricted to Registered users only Download (2MB)

Abstract

In recent years, chalcone and its derivatives have been studied extensively in terms of their biological activities. In this study, the synthesis and characterization of aspirin-chalcone derivatives has been carried out. A series of aspirin-chalcone derivatives were successfully synthesized from the reaction of intermediates 31a-c with acetylsalicyloyl chloride to yield final product of 32a-c with overall yield of 21.8 % to 88.4 %. All the derivatives were characterized by FT-IR, 1HNMR and 13CNMR. Disc diffusion method was then used to study the antibacterial activities of the new series. All of them showed the results of poor antibacterial properties. The structure that affected the strength of antibacterial properties was discussed.

Item Type:	Final Year Project Report
Additional Information:	Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2015.
Uncontrolled Keywords:	Aspirin, chalcone, aspirin derivatives, chalcone derivatives, antibacterial activities, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak
Subjects:	Q Science > QR Microbiology
Divisions:	Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User:	Saman
Date Deposited:	21 Mar 2018 08:59
Last Modified:	23 Feb 2024 08:54
URI:	http://ir.unimas.my/id/eprint/19905

Actions (For repository members only: login required)

View Item