Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh

Rosalind Pei Theng, Kim and Vicky, Bihud and Khalit, Mohamad and Kok Hoong, Leong and Jamaludin, Mohamad and Fasihuddin, Ahmad and Hazrina, Hazni and Noraini, Kasim and Siti Nadiah, Abdul Halim and Khalijah, Awang (2012) Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules. pp. 128-139. ISSN 1420-3049

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Official URL: doi:10.3390/molecules18010128

Abstract

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.

Item Type: Article
Uncontrolled Keywords: Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity, FSTS, 2012, Universiti Malaysia Sarawak, UNIMAS, universiti, university, Borneo, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education, undergraduate, research
Subjects: A General Works > AC Collections. Series. Collected works
A General Works > AC Collections. Series. Collected works
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 05 Dec 2013 02:31
Last Modified: 24 Jan 2022 06:40
URI: http://ir.unimas.my/id/eprint/97

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