Rosalind Pei Theng, Kim and Vicky, Bihud and Khalit, Mohamad and Kok Hoong, Leong and Jamaludin, Mohamad and Fasihuddin Badruddin, Ahmad and Hazrina, Hazni and Noraini, Kasim and Siti Nadiah, Abdul Halim and Khalijah, Awang (2012) Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules. pp. 128-139. ISSN 1420-3049
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Abstract
Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity, FSTS, 2012, Universiti Malaysia Sarawak, UNIMAS, universiti, university, Borneo, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education, undergraduate, research |
| Subjects: | A General Works > AC Collections. Series. Collected works |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Karen Kornalius |
| Date Deposited: | 05 Dec 2013 02:31 |
| Last Modified: | 29 Mar 2023 03:26 |
| URI: | http://ir.unimas.my/id/eprint/97 |
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