Characterization and expression studies of gigyf2 gene in danio rerio

Lim, Shing Yiing (2010) Characterization and expression studies of gigyf2 gene in danio rerio. [Final Year Project Report] (Unpublished)

PDF (Please get the password by email to repository@unimas.my, or call ext: 3914/ 3942/ 3933) Lim Shing Yiing ft.pdf Restricted to Registered users only Download (1MB)

Abstract

Grb 10 Interacting GYF protein 2 (GIGYF2) is one of the novel protein that interacts with growth factor receptor bound protein 10 (Grb10), an adapter protein that binds activated insulin-like growth factor I (IGF-I) and insulin receptors. The interaction suggests that the gene to be potentially involved in insulin and IGF signaling. The GIGYF2 gene is located within a region linked to familial Parkinson’s disease (PARK11 locus). Therefore, GIGYF2 represents a good candidate gene for PD. The expression of GIGYF2 gene was determined through RT-PCR of mRNA from ten isolated Danio rerio (zebrafish) organs, which include eye, gill, brain, heart, liver, intestine, stomach, skin, muscle and bone. The expression patterns of the GIGYF2 gene were compared between Danio rerio, human and mouse. Comparison showed that GIGYF2 gene was mainly expressed in insulin-targeted organs in Danio rerio and mammals.

Actions (For repository members only: login required)

View Item