Lewthwaite, Penny and Begum, Ashia and Ooi, Mong How and Faragher, Brian and Lai, Boon Foo and Sandaradura, Indunil and Mohan, Anand and Mandhan, Gaurav and Meharwade, Pratibha and Subhashini, S and Abhishek, Gulia and Begum, Asma and Penkulinti, Srihari and Shankar, M Veera and Ravikumar, R and Young, Carolyn and Cardosa, Mary Jane and Ravi, V and Wong, See Chang and Kneen, Rachel and Solomon, Tom (2010) Disability after encephalitis : development and validation of a new outcome score. Bull World Health Organ, 88 (8). pp. 584-592. ISSN 0042-9686
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Abstract
Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of current assessment tools, discussion with experts and a pilot study. The score was used to evaluate 100 children in Malaysia (56 Japanese encephalitis patients, 2 patients with encephalitis of unknown etiology and 42 controls) and 95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of unknown etiology and 18 controls). Inter- and intra-observer variability in the outcome score was determined and the score was compared with full clinical assessment. Findings: There was good inter-observer agreement on using the new score to identify likely dependency (Κ=0.942 for Malaysian children; Κ=0.786 for Indian children) and good intra-observer agreement (Κ=1.000 and 0.902, respectively). In addition, agreement between the new score and clinical assessment was also good (Κ=0.906 and 0.762, respectively). The sensitivity and specificity of the new score for identifying children likely to be dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India. Positive and negative predictive values were 84.2% and 100% in Malaysia and 65.6% and 100% in India. Conclusion The new tool for assessing disability in children after Japanese encephalitis was simple to use and scores correlated well with clinical assessment.
Item Type: | Article |
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Uncontrolled Keywords: | encephalitis, Japanese encephalitis, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak |
Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology > QR355 Virology R Medicine > R Medicine (General) |
Divisions: | Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine Faculties, Institutes, Centres > Institute of Health and Community Medicine |
Depositing User: | Ramji |
Date Deposited: | 16 Apr 2015 02:24 |
Last Modified: | 18 Mar 2022 08:36 |
URI: | http://ir.unimas.my/id/eprint/7009 |
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