Formaldehyde-Inactivated Whole-Virus Vaccine Protects a Murine Model of Enterovirus 71 Encephalomyelitis against Disease

Ong, Kien Chai and Devi, Shamala and Cardosa, Mary Jane and Wong, Kum Thong (2010) Formaldehyde-Inactivated Whole-Virus Vaccine Protects a Murine Model of Enterovirus 71 Encephalomyelitis against Disease. Journal Of Virology, 84 (1). pp. 661-665. ISSN 0022-538X

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=19864378

Abstract

Enterovirus 71 (EV71) causes childhood hand, foot, and mouth disease and neurological complications, and no vaccines or therapeutic drugs are currently available. Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis. After only two immunizations, given to mice at 1 and 7 days of age, the MAV vaccine protected mice at 14 days of age from disease. Tissues from immunized mice were negative for virus by viral culture, reverse transcriptase PCR, immunohistochemistry analysis, and in situ hybridization. Cross-neutralizing EV71 antibodies to strains with genotypes B3, B4, and C1 to C5 generated in immunized adult mice were able to passively protect 14-day-old mice from disease.

Item Type: Article
Uncontrolled Keywords: Enterovirus 71 (EV71), childhood hand, foot, and mouth disease, immunization, unimas, university, universiti, Borneo, Malaysia, Sarawak, kuching, samarahan, ipta, education, undergraduate, postgraduate, research, Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine
Faculties, Institutes, Centres > Institute of Health and Community Medicine
Depositing User: Ramji
Date Deposited: 10 Apr 2015 03:34
Last Modified: 10 Apr 2015 03:34
URI: http://ir.unimas.my/id/eprint/6978

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