Phytochemical studies and biological activities of goniothalamus malayanus

Siti Awanis, Binti Abdullah (2011) Phytochemical studies and biological activities of goniothalamus malayanus. [Final Year Project Report] (Unpublished)

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Abstract

The Phytochemical studies and biological activities of Goniothalamus malayanus have been conducted. The roots and stem barks of Goniothalamus malayanus were extracted with methanol and yield 13.08 g (1.31%) and 12.85 (0.71%) crude extract respectively. The methanol crude extract for both parts were partitioned using solvent with increasing polarity in the order of hexane, dichloromethane, chloroform and ethyl acetate. Ethyl acetate crude extract of the roots and DCM crude extract of the stem barks were subjected to column chromatography. For purification process, extensive column chromatography of the extracts gave one pure compound from the roots which was labeled as GMEtOAc7 and one semi pure compound from the stem barks and labeled as GMDCM6.7. Both compounds were subjected to various spectroscopic analyses such as IR, MS and NMR to elucidate the structure. Based on spectroscopic information, the compound isolated from both fractions was identified as goniothalamin. Ethyl acetate crude extract from the roots was toxic against Artemia salina which gave LC50 of 33.89 μg/mL while for the stem barks sample, dichloromethane crude extract was toxic against Artemia salina which gave LC50 value of 50.12 μg/mL. Ethyl acetate crude extract from roots of Goniothalamus malayanus was the most toxic against Coptotermes sp. that showed LC50 value of 1.50%. While for the stem barks of Goniothalamus malayanus, DCM crude extract was the most toxic against Coptotermes sp. that gave LC50value of 0.17%.

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