Synthesis of Molecularly Imprinted Polymers for the Extraction of p-Hydroxybenzoic Acid

Showkat Ahmad, Bhawani and AQIL FAIZ, MOHAMAD RAMEZAN, and Rachel Marcella, Roland and MOHAMAD AIMAN, OTHMAN and Aldrin Felix, Simbas (2025) Synthesis of Molecularly Imprinted Polymers for the Extraction of p-Hydroxybenzoic Acid. Asian Journal of Chemistry, 37 (7). pp. 1736-1742. ISSN 0975-427X

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Abstract

p-Hydroxybenzoic acid (p-HBA) is widely found in the environment due of its exceptional properties and has been used in the synthesis of variety of products such as preservatives, dyes, bactericides, etc. This causes a huge disposal of p-HBA in the environment which is considered to be harmful to both aquatic and terrestrial life. The molecular imprinting technique was employed to fabricate a molecularly imprinted polymer (MIP) that possesses selective binding sites for the p-HBA. In this study, p-HBA was used as the template molecule for the MIP synthesis, which was carried out using the precipitation polymerization method with a non-covalent approach. Acrylic acid was employed as the functional monomer, while ethylene glycol dimethylacrylate (EGDMA) was utilized as the cross-linker. The characterization of the MIP of p-HBA was conducted with scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). The SEM results showed that both MIP and the non-imprinted polymer (NIP) of p-HBA were spherical in shape. The MIP attained its highest efficiency at optimum conditions of 1 ppm initial concentration, 0.4 g of polymer dosage and 210 min contact time. Moreover, the competitive binding assay indicated that the MIP displayed a greater affinity towards p-HBA than benzoic acid. The synthesized MIP was successfully used for the extraction p-HBA from blood serum and the extraction efficiency was about 80.56%.

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