Effect of Green Polymerisation Via Microwave-Assisted Synthesis on Morphology, Size, and Rebinding Properties of Aspirinate Molecularly Imprinted Polymer

Vannessa, Lawai and Zainab, Ngaini and AHMAD ANIQ, NOOR BAHAR (2025) Effect of Green Polymerisation Via Microwave-Assisted Synthesis on Morphology, Size, and Rebinding Properties of Aspirinate Molecularly Imprinted Polymer. Journal of Sustainability Science and Management, 20 (2). pp. 273-282. ISSN 2672-7226

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Abstract

Molecularly imprinted polymer (MIP) has been vastly investigated for various applications, including drug delivery systems. Precipitation polymerisation has been widely used in the preparation of MIP to obtain small-sized polymer beads that are vital in drug delivery applications. However, the process requires a longer time and produces larger polymer particles, which often appear as a constraint for large-scale production and drug delivery applications. In this study, a series of MIPs were synthesised via microwave (MW) irradiation employing aspirin as a template in the presence of methacrylic acid (MAA) as functional monomer and divinylbenzene as crosslinker in acetonitrile at 80°C (MW80 in 60 minutes), 100°C (MW100 in 15 minutes), 110°C (MW110 in 8 minutes) and 120°C (MW120 in 4 minutes). MW110 produced homogeneous spherical particles (1.24 μm ± 0.17 μm), higher yield (0.62 g) and excellent rebinding capacity (7.27 mg/g) compared with other MIPs. Green synthesis of MIP via MW emerged as a powerful tool for well-controlled, rapid reactions and is significantly useful for drug delivery applications.

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