Huang, Mee Mee and Yiin, Chung Loong and Serene Lock, Sow Mun and Bridgid Chin, Lai Fui and Inawati, Othman and Nur Syuhada, Ahmad Zauzi and Chan, Yi Herng (2025) Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions. Journal of Molecular Liquids, 425 (127202). pp. 1-21. ISSN 0167-7322
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Abstract
The growing demand for sustainable and efficient extraction methods in phytochemical research has led to increasing interest in Natural Deep Eutectic Solvents (NADES) as eco-friendly alternatives for extracting bioactive compounds from medicinal plants. Unlike conventional solvents, NADES are non-toxic, biodegradable, and composed of natural, renewable materials, making them an attractive option for green extraction processes. This review aims to explore the potential of NADES as green solvents for extracting bioactive compounds from medicinal plants, focusing on recent advances, preparation methods, and their effectiveness in various plant extractions. The review also highlights the role of hydrogen bond donors (HBDs) in determining extraction efficiency, particularly for different bioactive compounds. While several reviews on NADES already exist, this work differentiates itself by providing a comprehensive comparison of various NADES formulations, discussing the impact of HBD choice on extraction efficiency, and identifying gaps in current research—particularly in optimizing NADES combinations for specific plant compounds. Additionally, the challenges and future directions for improving NADES-based extraction techniques are thoroughly discussed, paving the way for more sustainable and efficient extraction methods in the pharmaceutical and nutraceutical industries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Natural Deep Eutectic Solvents (NADES), Bioactive compounds Medicinal plants, Green extraction. |
| Subjects: | T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Engineering Faculties, Institutes, Centres > Faculty of Engineering |
| Depositing User: | Chung Loong |
| Date Deposited: | 24 Feb 2025 02:11 |
| Last Modified: | 24 Feb 2025 02:11 |
| URI: | http://ir.unimas.my/id/eprint/47640 |
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