Biosynthesized Persicaria odorata-silver nanoparticles supported zeolite Y as biocompatible antibacterial agent against Cutibacterium acnes

Muhammad Hariz, Asraf and Nik Ahmad Nizam, Nik Malek and Muhammad Redza, Mohd Radzi and Hendra, Susanto (2024) Biosynthesized Persicaria odorata-silver nanoparticles supported zeolite Y as biocompatible antibacterial agent against Cutibacterium acnes. Particuology, 93. pp. 1-10. ISSN 2210-4291

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Abstract

Conventionally synthesized silver nanoparticles (AgNP) imposed an alarming effect on the environment and caused toxicity to humans. However, the use of zeolite (zeoY) as a support system could increase its biocompatibility and reduce its toxicity. Hence, green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis technique. The phytochemical compounds in the optimized leaf extract concentration of 1% and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y pores. Morphological observation revealed the incorporation of AgNP in the zeolite Y (average size: 18.51 nm). The release of AgNP exhibited antibacterial activity on C. acnes at a concentration lower than 1 g L−1 which is also dependent on the electrolyte. AgNP-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model.

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