Carina M., Hall and Nawarat, Somprasong and Johannah P., Hagen and Roxanne, Nottingham and Jason W., Sahl and Jessica R., Webb and Mark, Mayo and Bart J., Currie and Yuwana, Podin and David M., Wagner and Paul, Keim and Herbert P., Schweizer (2023) Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei. Antimicrobial Agents and Chemotheraphy (2023). pp. 1-5. ISSN 0066-4804
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Abstract
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Burkholderia pseudomallei, cefiderocol, resistance |
| Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology R Medicine > RB Pathology |
| Divisions: | Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine Faculties, Institutes, Centres > Institute of Health and Community Medicine |
| Depositing User: | Ramji |
| Date Deposited: | 15 May 2023 02:44 |
| Last Modified: | 15 May 2023 02:44 |
| URI: | http://ir.unimas.my/id/eprint/41822 |
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