Bibliographic Analysis of Ribosomal Protein Genes for Small Ribosomal Subunit and Gene Expression Analysis of RPs11 in Nasopharyngeal Carcinoma Cells

Ling, Zhao Wen (2022) Bibliographic Analysis of Ribosomal Protein Genes for Small Ribosomal Subunit and Gene Expression Analysis of RPs11 in Nasopharyngeal Carcinoma Cells. [Final Year Project Report] (Unpublished)

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Abstract

The bibliography analysis considered many aspects including the author’s research area and article content. Nasopharyngeal carcinoma (NPC) is the fourth most frequent cancer in Malaysia. Previously, there is research about overexpression of ribosomal protein S11 (RPs11) correlates with tumor recurrence in diverse malignancies. However, there is a lack of research on the bibliographic analysis of ribosomal protein genes for small ribosomal subunits in nasopharyngeal carcinoma cells and research on RPs11 on NPC. Since the previous study found that high expression of RPs11 in colorectal cancer. Thus, a study on the gene expression analysis of RPs11 in nasopharyngeal carcinoma cells are carry out to understand the relationship between the RPs11 and NPC. The objective of this study was to identify the most country scientific publication, corresponding author’s country, and top 10 globally cited documents of ribosomal protein genes for small ribosomal subunit in NPC as well as to observe the RPs11 expression between NPC cell lines EBV infected NP460 and C666-1. Scopus was used to obtain data, selected the better literature with the PRISMA checklist, and then analyse with RStudio. In gene expression, M-MLVRT converted RNA to cDNA, PCR was performed and was observed. Malaysia has the highest frequency of scientific production among the country, which was 19, and the country led with 7 manuscripts and a frequency of 0.5833, SCP was 2, MCP was 5, and MCP ratio was 0.714. A total of 103 citations were made by LIU SC's publications in 2013, equating to 10.300 citations per year and 1.573 normalized total citations. For gene expression result, there was no observable differential expression detected.

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