Bibliographic Analysis of p53-Gene Family and Gene Expression Analysis of p73 in Nasopharyngeal Carcinoma

Aliza, Chung Yen Fang (2022) Bibliographic Analysis of p53-Gene Family and Gene Expression Analysis of p73 in Nasopharyngeal Carcinoma. [Final Year Project Report] (Unpublished)

	PDF ALIZA CHUNG YEN FANG 24pgs.pdf Download (1MB)
	PDF (Please get the password by email to repository@unimas.my , or call ext: 082-583914/3933/ 3942) ALIZA CHUNG YEN FANG ft.pdf Restricted to Registered users only Download (1MB)

Abstract

Nasopharyngeal Carcinoma (NPC) appears to be the most prevalent cancer specifically in East and Southeast Asia. NPC is a rare tumor occurs in the nasopharynx, often perceived at the pharyngeal recess or also known as fossa of Rosenmüller. p73 is known as the member of p53 family gene due to their allied in gene structure. Study suggests that the polymorphism of p73 responsible in mediating the nasopharyngeal carcinoma among Chinese populations. However, there is still lack of characterization between p73 gene and nasopharyngeal carcinoma. Apart from that, evidence showed that ribosomal proteins were vital as a tumor suppressor, gene-specific translational regulators, and oncogene. Therefore, the main purpose of this research is to perform a bibliographic analysis of the p53 in nasopharyngeal carcinoma publications and to compare the expression p73 gene in NPC cell lines by RT-PCR. PCR result revealed that the expected product size of p73 gene was 994bp. Smeared bands were obtained on the p73 in both NP69, and SUNE-1 cell lines. Possibilities of the smeared result of p73 was discussed in this study.

Actions (For repository members only: login required)

View Item