Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana

Karunakaran, Thiruventhan and Ee, Gwendoline C.L. and Tee, Keng H. and Ismail, Intan S. and Zamakshshari, Nor H. and Peter, Waziri M. (2016) Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana. Phytochemistry Letters, 17 (2016). pp. 131-134. ISSN 1874-3900

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Abstract

Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested againsttwo cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTTassays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT29 cell line

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