SYNTHESIS OF BENZALDEHYDE DERIVATIVES ASANTIOXIDANT AGENT ASSISTED BY PHARMACOPHORE MODELLING (Acne vulgaris)

Nurul Amani, Mohd Zaini (2019) SYNTHESIS OF BENZALDEHYDE DERIVATIVES ASANTIOXIDANT AGENT ASSISTED BY PHARMACOPHORE MODELLING (Acne vulgaris). [Final Year Project Report] (Unpublished)

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Abstract

Acne Vulgaris is a common chronic inflammatory skin disease which affecting adolescents and often continuing into adulthood. This pilosebaceous units of the skin affected and causes inflammatory or non-inflammatory lesions. The development of cutaneous inflammatory diseases is caused by inadequate antioxidant protection and or excess reactive oxygen species (ROS) production that creates a condition known as oxidative stress. This project was carried out to synthesize anti-oxidant agent for acne vulgaris through Schiff base reaction and pharmacophore modelling by using benzaldehyde derivatives. Compound that has been synthesized was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thin Layer Chromatography (TLC) technique and Nuclear Magnetic Resonance 1H NMR. This project was facilitated by using pharmacophore modelling to search anti-acne drugs. Pharmacophore model was developed by using Liganscout 4.3 software. The pharmacophore model is developed from three training sets that was selected from established ant-acne drugs. The best model was validated with 10 test sets from the synthesized compound. The validation shows that compound 10 and compound 9 has the highest pharmacophore fit-value. The cytotoxicity assay using brine shrimp (Artemia salina) and antioxidant assay using diphenylpicrylhydrazyl (DPPH) radical was conducted. From the results, compound 9 is the most effective anti-oxidant agent than the other compounds

Item Type:	Final Year Project Report
Additional Information:	Project report (BAA) -- Universiti Malaysia Sarawak, 2019.
Uncontrolled Keywords:	Acne vulgaris, pharmacophore, benzaldehyde, Schiff base, Artemia salina, antioxidant
Subjects:	Q Science > QD Chemistry
Divisions:	Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User:	Dan
Date Deposited:	08 Nov 2021 02:09
Last Modified:	08 Nov 2021 02:09
URI:	http://ir.unimas.my/id/eprint/36629

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