Identification of Protein Partners of the Human Ribosomal Protein, uS19 Using Bioinformatics Analysis

Daphne Olivia Jawai, Sadai Identification of Protein Partners of the Human Ribosomal Protein, uS19 Using Bioinformatics Analysis. [Final Year Project Report] (Unpublished)

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Abstract

The role of human ribosomal protein, uS19 is not only bound in forming intersubunit between small and large subunits of a ribosome but also has extra-ribosomal roles which are causing a few type of diseases and cancers. Although many studies have been carried out to identify the functions of this protein, the information on the functions are still insufficient and limited. The approach to identify the functions of this protein is by identification of the predicted protein's partners of the human ribosomal protein, uS 19 and docking stimulation of the protein with protein partners through bioinformatics analysis. This analysis is based on sequences, structure and associated proteins which is known as sequence-to-structure-to-function paradigm. Besides, this analysis involves the construction of predicted three-dimensional (3D) model of uS19 ribosomal protein and the identification of structural neighbour and protein partners. The identified protein partners are used in molecular docking stimulation to the uS 19 ribosomal protein. After the analysis of docked uS 19 ribosomal protein with the identified protein partners, three logical docked structures were revealed. This is the docking of uS 19 ribosomal protein with two different domains of the Fragile X Mental Retardation protein (FMRP) and one domain of Transducer of ERBB2.1 (TOB 1) protein. Hence, the study enable the recognition predicted extra-ribosomal functions of ribosomal protein, uS 19.

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