Cynometra cauliflora L.: An indigenous tropical fruit tree in Malaysia bearing essential oils and their biological activities

Benedict, Samling and Zaini, Assim and Tong, Woei-Yenn and Leong, Chean-Ring and Syarifah, Ab Rashid and Nik Nur Syazni, Nik Mohamed Kamal and Musthahimah, Muhamad and Tan, Wen-Nee (2021) Cynometra cauliflora L.: An indigenous tropical fruit tree in Malaysia bearing essential oils and their biological activities. Arabian Journal of Chemistry, 14 (9). pp. 1-12. ISSN 1878-5352

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Abstract

Cynometra cauliflora L., locally known as ‘‘nam-nam” or ‘‘katak puru-puru” in Malaysia is belonging to the Fabaceae family. The tree is native to Malaysia and has been used traditionally as folk medicine. Limited works have been conducted on C. cauliflora regarding its chemical composition. In view of this, the present study aimed to identify the essential oil (EO) composition of the leaf, twig and fruit of C. cauliflora and evaluate their antioxidant, antimicrobial and cytotoxic activities. EOs obtained from different parts of the tree were analyzed using capillary GC and GC/MS. Twenty-six, seventeen and fifty constituents were identified in the leaf, twig and fruit EOs of C. cauliflora. Results demonstrated the dominance of monoterpenes hydrocarbons in the leaf oil and oxygenated monoterpenes in the twig oil. On the contrary, fruit oil was abundant in oxygenated sesquiterpenes. Different chemical profiles were found in different parts of EOs which have contributed to varied biological activities. Twig oil (IC50 37.12 ± 2.84 mg/mL) showed better antioxidant power than the leaf (IC50 207.17 ± 2.95 mg/mL) and fruit oils (IC50 461.88 ± 12.61 mg/mL) in DPPH assay. Additionally, twig oil inhibited an entire range of microorganisms tested with inhibition zones ranging 10.3 ± 0.4 to 29.7 ± 0.4 mm. The twig oil displayed low MIC and MBC values against Staphylococcus aureus (MIC 125.0 mg/mL; MBC 250.0 mg/mL) and MRSA (MIC 125.0 mg/mL; MBC 250.0 mg/mL). In in vitro MTT assay, twig oil showed antiproliferative effects against human breast cancer MCF-7 cells.

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