Vannessa, Lawai and Zainab, Ngaini (2021) Chitosan magnetic nanocomposites for gene delivery. In: Polysaccharide-Based Nanocomposites for Gene Delivery and Tissue Engineering. Woodhead Publishing, United Kingdom, pp. 279-294. ISBN 978-0-12-821230-1
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Abstract
The application of magnetic nanoparticles coated with cationic polymers in the biomedicine field has been studied extensively. The biological properties of chitosan and magnetic nanoparticles such as biocompatibility, biodegradability, and targeted delivery make nanocomposites an excellent choice in gene delivery systems. Several methods of preparing nanocomposites have been reported (i.e., microemulsion, thermal decomposition, solvothermal), which mostly are expensive and tedious methods. The coprecipitation method is widely employed and able to produce uniform and small particle sizes, which are highly suitable for gene delivery. The high transfection efficiency of chitosan magnetic nanocomposite was tested in vitro and in vivo against cancerous cells (B16F10 murine melanoma cells, SF767 human glioblastoma) and normal cells (HEK-293T). In vivo magnetofection study indicated the efficiency and applicability of chitosan magnetic nanocomposites for gene delivery.
| Item Type: | Book Chapter |
|---|---|
| Uncontrolled Keywords: | Gene deliveryChitosanMagnetic nanoparticlesCationic polymerCoprecipitation, UNIMAS, University, Borneo, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education, Universiti Malaysia Sarawak |
| Subjects: | Q Science > Q Science (General) S Agriculture > S Agriculture (General) |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Sanawi |
| Date Deposited: | 17 Jun 2021 08:37 |
| Last Modified: | 17 Jun 2021 08:37 |
| URI: | http://ir.unimas.my/id/eprint/35496 |
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