Farooq, Saba and Zainab, Ngaini (2021) One-pot and two-pot methods for chalcone derived pyrimidines synthesis and applications. Journal of Heterocyclic Chemistry, 1 (1). pp. 1-16. ISSN 1943-5193
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Abstract
Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pyrimidines, chalcone, present in ribonucleic acid (RNA), deoxyribonucleic acid (DNA), amino derivatives. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Ngaini |
| Date Deposited: | 26 Feb 2021 02:25 |
| Last Modified: | 26 Feb 2021 02:25 |
| URI: | http://ir.unimas.my/id/eprint/34569 |
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