Chai, Tchan Wei (2014) Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities. [Final Year Project Report] (Unpublished)
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Abstract
A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E. Coli while compound 20 showed good activity against E. Coli.
| Item Type: | Final Year Project Report |
|---|---|
| Additional Information: | Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2014. |
| Uncontrolled Keywords: | Aspirin, Thiourea, Antibacterial activity, Escherichia Coil |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Unai |
| Date Deposited: | 17 Feb 2021 08:06 |
| Last Modified: | 30 Jan 2023 08:17 |
| URI: | http://ir.unimas.my/id/eprint/34435 |
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