Ho, Ket Wah (2014) Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site. [Final Year Project Report] (Unpublished)
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Abstract
Reported cases of Mycobacterium tuberculosis (Mtb) infection in Pongo pygmaeus (Bornean orangutan) have been alarming as threat. The present study looks on the pharmacophore modelling of the Mtb active site (from Protein Data Bank, PDB) with the conventional tuberculosis regimens such as rifampin, isoniazid, pyrazinamide, ethambutol and streptomycin and potential tuberculosis regimens include fluoroquinolones and diarylquinoline. Pharmacophore modelling was performed using Ligandscout 3.10 to search the potential tuberculosis regimen using structure based. Screening among the seven regimens used, only four regimens which are ethambutol, rifampin, streptomycin and fluoroquinolones have shared similar features to generate phamarcophore with Mtb active site.
| Item Type: | Final Year Project Report |
|---|---|
| Additional Information: | Project report (B.Sc.) -- Universiti Malaysia Sarawak, 2014. |
| Uncontrolled Keywords: | Mycobacterium Tuberculosis, pharmacophore modelling, Pongo pygmaeus. |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Patrick |
| Date Deposited: | 23 Nov 2020 03:55 |
| Last Modified: | 19 Oct 2023 08:40 |
| URI: | http://ir.unimas.my/id/eprint/32893 |
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