Synthesis, Characterization And Biological Studies Of Organotin(Iv) Complexes Of Thiosemicarbazone Ligand Derived From Pyruvic Acid: X-Ray Crystal Structure Of [Me2sn(Pat)]

Zainab, Ngaini and Md. Abu, Affan and Foo, Siong Wan and Mustaffa, Shamsuddin (2009) Synthesis, Characterization And Biological Studies Of Organotin(Iv) Complexes Of Thiosemicarbazone Ligand Derived From Pyruvic Acid: X-Ray Crystal Structure Of [Me2sn(Pat)]. The Malaysian Journal of Analytical Sciences, 13 (1). pp. 63-72. ISSN 1394-2506

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Abstract

Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR, 1 H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia salina, shrimp test lethality bioassay.

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