Chin, Suk Fun and Asniar, Binti Salim and Pang, Suh Cem (2020) Hydroxypropyl Starch Nanoparticles as Controlled Release Nanocarriers for Piperine. Journal of Nanostructures, 10 (2). pp. 327-336. ISSN 2251-788X
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Abstract
Hydroxypropyl starch was synthesized by modified sago starch with hydroxypropylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm are obtained by controlled precipitation through the drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Piperine was loaded onto hydroxypropyl starch nanoparticles and native starch nanoparticles via the in-situ nanoprecipitation process. Hydroxypropyl starch nanoparticles exhibited higher piperine loading capacity as compared to native starch nanoparticles with the maximum loading capacity of 0.46 and 0.33 mg.mg-1, respectively. Piperine was release from hydroxypropyl starch nanoparticles in a slow and sustained manner at pH 1.2 over the period of 24 hours. Whereas piperine was completely released from native starch nanoparticles within 16 hours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Controlled Release, Hydroxypropyl Starch, Nanoparticles Piperine, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
| Depositing User: | Fun |
| Date Deposited: | 19 May 2020 07:28 |
| Last Modified: | 08 Apr 2021 03:23 |
| URI: | http://ir.unimas.my/id/eprint/29758 |
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