Reversed phase thin layer chromatography of five co-administered drugs with surfactant modified solvent systems

Bhawani, Showkat Ahmad and Ali, Mohammad and Sharma, Sudhanshu (2009) Reversed phase thin layer chromatography of five co-administered drugs with surfactant modified solvent systems. Indian Journal of Chemical Technology (IJCT), 16 (4). pp. 344-350. ISSN 0975-0991

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Official URL: http://nopr.niscair.res.in/handle/123456789/5916

Abstract

The chromatography of five co-administered drugs i.e. paracetamol, ibuprofen, diclofenac sodium, aspirin and ascorbic acid was performed on various reversed phase layers. The surfactant mediated solvent systems were used with various impregnated silica gel H layers for the chromatography of these five drugs. The various experimental conditions were optimized for the selection of optimum concentration of impregnants. The mutual separation of a mixture of paracetamol, diclofenac sodium and ibuprofen; and paracetamol, aspirin and ascorbic acid are achieved on various impregnated silica gel H layers, using surfactant mediated solvent systems containing n-hexane: 1% CTAB in MeOH: ethyl acetate: acetic acid, (13:1:4:2, v/v) and toluene: 1% CTAB in MeOH: n-propanol: formic acid, (14:1:3:2, v/v) respectively.

Item Type: Article
Uncontrolled Keywords: Thin layer chromatography; Paracetamol; Diclofenac sodium; Ibuprofen; Aspirin ;Ascorbic acid, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User: Gani
Date Deposited: 13 May 2020 03:19
Last Modified: 13 May 2020 03:19
URI: http://ir.unimas.my/id/eprint/29694

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