Staphyphage: Biorisk Reduction in MRSA Research

Tan, Cheng Siang and Nurul Aqilah, Binti Aqiludeen and Gowbei, Annabel and Mijen Beemer, Alexander and Santhana, Raj L. and SIti Fairouz, Binti Ibrahim (2017) Staphyphage: Biorisk Reduction in MRSA Research. In: 12th Asia-Pacific Biosafety Association Conference, 22-25 August 2017, Ho Chi Minh.

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Abstract

Staphylococcus aureus is an opportunistic human pathogen that has the ability to cause both health care-associated and community-acquired infections [1]. It has been identified as one of the ‘high priority pathogen’ by the World Health Organization (WHO) [5] The infections were once, easily treated with antibiotics before resistance against beta-lactams (eg. Methicillin) and glycopeptides (eg. Vancomycin) began to emerge over the years and caused an increase in mortality and morbidity rates in patients infected with S. aureus [2,3]. This has led to an increased interest in the exploration of the use of bacteriophage as an alternative approach way to combat MRSA because a bacteriophage has bacteriolytic mechanism independent from those of any known antibiotics [5]. The availability of a virulent and broad spectrum bacteriophage against MRSA may significantly reduce the overall biorisk as it acts as an effective treatment in case of exposure.

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