Computational inferences of molecular phylogeny among the ribosomal protein genes encoding products for small ribosomal subunit

Nur Suriati, Binti Pabilah. (2015) Computational inferences of molecular phylogeny among the ribosomal protein genes encoding products for small ribosomal subunit. [Final Year Project Report] (Unpublished)

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Abstract

One of the methods in comparative genomics is phylogenetic analysis where it is used extensively in determining evolutionary relationship of genes across the species. In this analysis, the evolutionary relationship of 31 ribosomal protein genes (RPG) encoding for small eukaryotic ribosomal subunit (40S) across 20 targeted species that have homologous relationship with Homo sapiens RPG were investigated by the construction of phylogenetic tree using the approach of maximum likelihood (ML) through application of MEGA software. All the sequences retrieved are collected from public databases such as GenBank, UniProt and RefSeq. The analysis shows that RPGs are highly conserved throughout the species and the rate of evolution is constant throughout different types of 40S RP though slight variation in the clustering group is shown in the phylogenetic tree. RPG is a very important component since its function involves biogenesis to produce essential proteins in an organism thus high level of gene conservation are expected. This analysis are able to provide fundamental knowledge of the event of molecular evolution that occurs across the time between 20 homologs of eukaryote 40S RP.

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