Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction

Asri, Bin Said and Ho, Kian Hui and Jong, Siu Mei and Fong, Alan Yean Yip and Huang, Siaw San and Syed Hazran, Bin Syed Mohammad and Lee, James Zhi Yuan and Chew, Rebecca Su Li and Naemah, Binti Mazlan and Koh, Keng Tat and Shu, Francis Eng Pbeng and Tan, Chen Ting and Oon, Yen Yee and Foo, Diana Hui Ping and Nor Hanim, Binti Mohd Amin and Cham, Yee Ling and Khiew, Ning Zhan and Voon, Chi Yen and Ong, Tiong Kiam (2018) Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction. International Journal of Cardiology, 273 (Supp). p. 3. ISSN 0167-5273

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Abstract

Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusive. Objective: To investigate the relationship between LTL and developing AMI, the association of LTL with inpatient and 30-day mortality, and the comparison to LTL with established AMI risk scores in predicting these outcomes. Methodology: 100 patients aged 30-70 years admitted with an AMI to a tertiary referral center between May-Oct 2017 were enrolled; these were matched with 100 non-AMI ('healthy') controls for gender and age (+/- 1 year). Clinical data was obtained prospectively; inpatient and 30-day outcomes documented. LTL was reflected by a well described variable called a tis ratio (TSR). The TSR was measured at enrolment using a quantitative PCR-based methods (qPCR) and results blinded to the clinician.

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