Association between Clinical Parameters and CRT Response

Asri, Bin Said and Shu, F.E.P. and Voon, C.Y. and Ho, K. H. and Tan, C. T. and Koh, K. T, and Oon, Y.Y. and Cham, Y. L. and Nor Hanim, M. A. and Khiew, N.Z. and Fong, A.Y.Y. and Ong, T.K. (2018) Association between Clinical Parameters and CRT Response. International Journal of Cardiology, 273 (Supp). p. 6. ISSN 0167-5273

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Abstract

Background: CRT is indicated for patients with severely impaired left ventricular systolic function and ventricular dyssynchrony who remain symptomatic despite optimal medical therapy. CRT is an expensive treatment with a significant non-responder rate. Objective: To ensure appropriate use of this treatment modality, we decided to investigate whether clinical parameters can predict response to CRT in our patients. Methods: We retrospectively reviewed all CRT patients under responder based on pre-specified ECHO and clinical criteria. An ECHO response would be: relative improvement from baseline left ventricular ejection fraction (EF) of N 15%; and a decrease in End Diastolic Volume index (EDVi) or End Systolic Volume index (ESVi) of N 15%. Clinical response was defined as an improvement of at least 1 NYHA functional class. Patients who fulfil both ECHO and clinical criteria are considered responders our follow-up since 2014. We classified them as responder or non.

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