Tiong, Wen Ni. (2012) Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome. Masters thesis, Universiti Malaysia Sarawak, (UNIMAS).
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Abstract
Inflammation, endothelial dysfunction and platelet activation play an important role in pathogenesis of vulnerable plaques of acute coronary syndrome (ACS). However little is known about the inter-relation of these in early phase of ACS. This study sought to determine a possible multimarker strategy by linking three indices to provide an early assessment of the risk of ACS. Serum protein and gene expression level of interleukin-6 (IL6;biomarker of inflammation), von willebrand Factor (VWF; biomarker of endothelial dysfunction) and soluble P-selectin (SELP; biomarker of platelet activation) were measured in 22 patients with ACS (age 55.2+10.4 years) and 28 controls with angiographically documented occlusive coronary atery disease (CAD) without previous ACS events (age 53.5+8.4 years).
Item Type: | Thesis (Masters) |
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Additional Information: | Thesis (M.Sc.) -- Universiti Malaysia Sarawak, 2012. |
Uncontrolled Keywords: | Inflammation, Pathophysiology, Acute coronary syndrome, interleukin-6, von Willebrand Factor, P-selectin, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education,Postgraduate, research, Universiti Malaysia Sarawak |
Subjects: | R Medicine > RB Pathology |
Divisions: | Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology Faculties, Institutes, Centres > Faculty of Resource Science and Technology |
Depositing User: | Karen Kornalius |
Date Deposited: | 03 May 2016 02:27 |
Last Modified: | 03 May 2023 08:38 |
URI: | http://ir.unimas.my/id/eprint/11818 |
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