Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach

Nazatul Syahira, bt. Roslan (2015) Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach. [Final Year Project Report] (Unpublished)

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Abstract

Ribosomal proteins (RPs) are the main component of ribosomes and play important roles in protein biosynthesis. Besides, several of them are shown to have extraribosomal functions. In this research, we used bioinformatics approach in finding the interaction between the ribosomal protein S3 (RPS3) and ribosomal protein S12 (RPS12) with their protein partners. Our results discovered that RPS3 interacts with Epidermal Growth Factor Receptor (EGFR) and 14-3-3 protein epsilon (YWHAE). RPS3 is predicted to inhibit the function of EGFR and YWHAE. RPS12 interacts with Transcription Elongation Factor B Polypeptide (ELOB) and Ski-like protein (SKIL). Hence, it is predicted to interrupt the function of ELOB and SKIL.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2015.
Uncontrolled Keywords: Ribosomal protein, Ribosomal protein S3, Ribosomal protein S12, Extraribosomal functions, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, research, Universiti Malaysia Sarawak
Subjects: Q Science > Q Science (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User: Karen Kornalius
Date Deposited: 11 Feb 2016 07:55
Last Modified: 11 Feb 2016 07:55
URI: http://ir.unimas.my/id/eprint/10517

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