Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians

Mohd Aminudin, Mustapha and Siti Nurfatimah, Mohd Shahpudin and Ahmad Aizat, Abdul Aziz and Ankathil, Ravindran (2012) Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians. World Journal of Gastroenterology., 18 (21). pp. 2668-2673. ISSN 2219 - 2840

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AIM: To investigate the allele and genotype frequencies and associated risk of interleukin (IL )-8 -251T>A polymorphism on colorectal cancer (CRC) susceptibility risk. METHODS: Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients were genotyped for IL-8 -251T>A polymorphism employing allele-specific polymerase chain reaction. The relative association of variant allele and genotypes with CRC susceptibility risk was determined by calculating the odds ratios (ORs). Corresponding χ 2 tests on the CRC patients and controls were carried out and 95% confidence intervals (CIs) were determined using Fisher’s exact test. The allele frequencies and its risk association were calculated using FAMHAP, haplotype association analysis software. RESULTS: On comparing the frequencies of genotypes of patients and controls, the homozygous variant AA was significantly higher in CRC patients (P = 0.002) compared to controls. Investigation on the association of the polymorphic genotypes with CRC susceptibility risk, showed that the homozygous variant IL-8 -251AA had a significantly increased risk with OR 3.600 (95% CI: 1.550-8.481, P = 0.001). In the case of allele frequencies, variant allele A of IL-8 -251 showed a significantly increased risk of CRC predisposition with OR 1.32 (95% CI: 1.03-1.69, P = 0.003). CONCLUSION: Variant allele and genotype of IL-8 (-251 T>A) was significantly associated with CRC susceptibility risk and could be considered as a high-risk variant for CRC predisposition.

Item Type: Article
Additional Information: University Malaysia Sarawak, UNIMAS
Uncontrolled Keywords: Interleukin-8 -251T>A, Polymorphism, Colorectal cancer, Malaysians, Unimas, univeristy, universiti, borneo, Malaysia, Sawak, Kuching, Samarahan, ipta, education, undergraduate, postgraduate, research
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Centre for Pre-University Studies
Depositing User: Karen Kornalius
Date Deposited: 03 Mar 2014 01:02
Last Modified: 10 Sep 2015 07:34
URI: http://ir.unimas.my/id/eprint/734

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