Polymorphism in the tumor necrosis factor alpha promoter region and its influence on colorectal cancer predisposition risk in Malaysian population

Mohd Aminudin, Mustapha and Siti Nurfatimah, Mohd Shahpudin and Ahmad Aizat, Abdul Aziz and Bhavaraju, Venkata Muralikrishna and Naik, Venkatesh R and Zaidi, Zakaria and Ahmad Shanwani, Mohd Sidek and Mohammad Radzi, Abu Hasan and Ankathil, Ravindran (2011) Polymorphism in the tumor necrosis factor alpha promoter region and its influence on colorectal cancer predisposition risk in Malaysian population. International Medical Journal, 18 (4). pp. 275-278.

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Abstract

objective:A case control study was designed to investigate the TNF-a -308 G>A polymorphism allele frequencies and to determine the influence of the polymorphic genotype on sporadic CRC susceptibility risk in Malaysia population. Material and methods: Peripheral blood samples of 164 normal controls and 161 clinically and histopathhologically confirm CRC patients were genotyped for TNF-a -308 G>A polymorphism employing allele specific PCR. The relative associations of various genotypes with CRC susceptibility risk was determined by calculating Odd ratios. Corresponding Chi-square tests on CRC patients and controls were carried out and 95% confidence interval (95% CI) were determined using fisher exact tests. Results: On comparing the frequencies of genotypes of patients and controls, the homozygous variant AA was significabtly higher in CRC patients (p=0.030) compared to controls. On investigating the association of the polymorphic genotypes with CRC susceptibility risk, the homozygous variant TNF-a -308AA showed significantly increased risk with OR 2.5842. Conclusion: Our results suggest that, polymorphic genotype of inflammation response gene TNF-a is significantly associated with CRC susceptibility risk and colud be considered as a high risk variant for CRC predisposition.

Item Type: E-Article
Uncontrolled Keywords: colorectal cancer, inflammation response gene, TNF-a, plymorphism, UNIMAS, Universiti Malaysia Sarawak, IPTA, education, university, universiti, borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, undergraduate, postgraduate, research
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Centre for Pre-University Studies
Depositing User: Karen Kornalius
Date Deposited: 26 Feb 2014 04:26
Last Modified: 08 Jul 2019 00:23
URI: http://ir.unimas.my/id/eprint/706

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