Clinical features, diagnosis, and management of enterovirus 71

Ooi, Mong How and Wong, See Chang and Lewthwaite, Penny and Cardosa, Mary Jane and Solomon, Tom (2010) Clinical features, diagnosis, and management of enterovirus 71. The Lancet Neurology, 9 (11). pp. 1097-1105. ISSN 1474-4422

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Abstract

Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction.

Item Type: Article
Uncontrolled Keywords: enterovirus 71, diagnosis, virus, diseases, research, Universiti Malaysia Sarawakunimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education,
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Institute of Health and Community Medicine
Depositing User: Ramji
Date Deposited: 14 Apr 2015 08:09
Last Modified: 14 Apr 2015 08:09
URI: http://ir.unimas.my/id/eprint/7019

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