Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses

Vasilakis, Nikos and Cardosa, Mary Jane and Sall, Amadou A. and Diallo, Mawlouth and Holmes, Edward C. and Hanley, Kathryn A. and Weaver, Scott C. (2010) Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses. Journal Of Virology, 84 (7). pp. 3726-3728. ISSN 0022-538X

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Abstract

Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years.

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