Impact of the Probiotic on the Modulation of Vaginal Bacterial and Fungal Microbiota in HPV‐Positive Women

Pei, Xu and Mageswaran Uma, Mageswary and Azka Ainun, Nisaa and Shandra Devi, Balasubramaniam and Sarah, Binti Samsudin and Nurul Izza, Binti Mohamed Rusdi and Abigail Rembui, Jerip and Chern Ein, Oon and Mohamad Hafizi, Abu Bakar and Jun Jie, Tan and Fatin Fazrina, Roslan and Muhammad Nashriq, Kadir and Engku Husna, Engku Ismail and Salina, Sany and Cheng Siang, Tan and Min Tze, Liong (2025) Impact of the Probiotic on the Modulation of Vaginal Bacterial and Fungal Microbiota in HPV‐Positive Women. Molecular Nutrition & Food Research, 2025 (e70142). pp. 1-12. ISSN 1613-4133

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Abstract

This study examined the effects of administering the probiotic Lactiplantibacillus plantarum Probio87 on the vaginal microbiota of HPV-positive women, highlighting alterations in bacterial and fungal communities and their potential influence on vaginal and overall health. In a double-blind, randomized, placebo-controlled study, participants consumed daily doses of Probio87 (1 × 109 CFU/sachet) or a placebo for 12 weeks. Vaginal swabs were collected, and DNA was extracted for 16S rRNA and the internal transcribed spacer (ITS) region amplification via PCR, followed by sequencing of bacterial and fungal microbiota. The probiotic group showed improved alpha and beta diversity, with an increase in beneficial Lactobacillus (p = 0.014) and Phascolarctobacterium faecium (p = 0.041), while decreasing the abundance of pathogens like Streptococcus and Candida (p = 0.011). Additionally, vaginal health questionnaires linked probiotic use to improved vaginal and mental health in HPV-positive women. L. plantarum Probio87 demonstrated clinical and psychological benefits in HPV-positive women by balancing the vaginal microbiome, reducing pathogenic species, and promoting the growth of beneficial microorganisms.

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