Design and fabrication of metered dose nasal spray

Jameson, Gan (2008) Design and fabrication of metered dose nasal spray. [Final Year Project Report] (Unpublished)

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Nasal sprays are used for the nasal delivery of drugs. These drugs generally are used to alleviate cold or allergy symptoms such as nasal congestion. Nasal sprays generally consist of four parts which is the container closure system, pump mechanism, bottle cap and the nozzle. Atomizer had been used in the applications of nasal spray for some time. Atomization is the process of converting a bulk liquid into a cluster of spray or mist. Axiomatic Design is used to identify the weaknesses associated with the existing nasal spray. A new design is proposed to improve the weaknesses and effectiveness. A pressure-swirl atomizer is utilized to create better atomization and mixing of drugs. Pressure-swirl atomizer creates a wider spray angle and mistier spray droplets. The pressure- swirl nozzle produces a solid cone spray and distributes the drug evenly in small liquid droplets. This will increase the rate of absorption into nasal moist wall. CATIA V4® software is used to create the design the component blueprint. Fabrication is done using CNC machine for better strength. Meanwhile, the COSMOSFloWorks® 2004 is used to simulate the flow inside the nozzle with a predetermined parameter. The pressure and inlet volume flow are also determined. Experiments are done to determine the spray pattern and angle of spray dispersion.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2008.
Uncontrolled Keywords: Medical technology, Medical innovations, Engineering, 2008, UNIMAS, Universiti Malaysia Sarawak, research, undergraduate, nasal spray, atomization, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, IPTA, education
Subjects: R Medicine > R Medicine (General)
T Technology > T Technology (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Engineering
Depositing User: Karen Kornalius
Date Deposited: 25 Aug 2014 02:33
Last Modified: 29 Jun 2021 13:16

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