Mapping human genetic diversity in Asia

MA, Abdulla and I, Ahmed and A, Assawamakin and J, Bhak and SK, Brahmachari and GC, Calacal and A, Chaurasia and CH, Chen and J, Chen and YT, Chen and J, Chu and EM, Cutiongco-de la Paz and MC, De Ungria and FC, Delfin and J, Edo and S, Fuchareon and H, Ghang and T, Gojobori and J, Han and SF, Ho and BP, Hoh and W, Huang and H, Inoko and P, Jha and Timothy Adrian, Jinam and L, Jin and J, Jung and D, Kangwanpong and J, Kampuansai and GC, Kennedy and P, Khurana and HL, Kim and K, Kim and S, Kim and WY, Kim and K, Kimm and R, Kimura and T, Koike and S, Kulawonganunchai and V, Kumar and PS, Lai and JY, Lee and S, Lee and ET, Liu and PP, Majumder and KK, Mandapati and S, Marzuki and W, Mitchell and M, Mukerji and K, Naritomi and C, Ngamphiw and N, Niikawa and N, Nishida and B, Oh and S, Oh and J, Ohashi and A, Oka and R, Ong and CD, Padilla and P, Palittapongarnpim and HB, Perdigon and Maude E., Phipps and E, Png and Y, Sakaki and JM, Salvador and Y, Sandraling and V, Scaria and M, Seielstad and MR, Sidek and A, Sinha and M, Srikummool and H, Sudoyo and S, Sugano and H, Suryadi and Y, Suzuki and KA, Tabbada and A, Tan and K, Tokunaga and S, Tongsima and LP, Villamor and E, Wang and Y, Wang and H, Wang and JY, Wu and H, Xiao and S, Xu and JO, Yang and YY, Shugart and HS, Yoo and W, Yuan and G, Zhao and BA, Zilfalil and Indian Genome Variation, Consortium (2009) Mapping human genetic diversity in Asia. Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075

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Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Item Type: Article
Uncontrolled Keywords: human genetic diversity, genome-wide, Southeast Asian (SEA) and East Asian (EA).
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Joseph Jinam
Date Deposited: 12 Jul 2023 03:47
Last Modified: 12 Jul 2023 03:47

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