Risk Factors for Enterovirus A71 Seropositivity in Rural Indigenous Populations in West Malaysia

Nik Nadia, NMN and Sam, I Ching and Nasibah, Khaidir and Romano, Ngui and Yvonne Ai, Lian Lim and Xiang, Ting Goh and Seow, Huey Choy and Yoke, Fun Chan (2016) Risk Factors for Enterovirus A71 Seropositivity in Rural Indigenous Populations in West Malaysia. PLOS ONE, 11 (2). pp. 1-10. ISSN 1932-6203

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Enterovirus A71 (EV-A71), which is transmitted by the fecal-oral route, causes hand, foot and mouth disease and, rarely, severe neurological complications. In Malaysia, the indigenous rural community (Orang Asli) has a high prevalence of parasitic diseases due to poor sanitation, water supply and hygiene practices. This cross-sectional study compared the seroepidemiology of EV-A71 among rural Orang Asli and urban Kuala Lumpur populations in West Malaysia, and determined the risk factors associated with EV-A71 seropositivity in rural Orang Asli. Seropositive rates were determined by neutralization assay. EV-A71 seropositivity was strongly associated with increasing age in both populations. Rural Orang Asli children �12 years had significantly higher EV-A71 seropositivity rates than urban Kuala Lumpur children (95.5% vs 57.6%, P < 0.001), and also higher rates in the age groups of 1–3, 4–6 and 7–12 years. Multivariate analysis confirmed that age �12 years (adjusted OR 8.1, 95% CI 3.2–20.7, P < 0.001) and using untreated water (adjusted OR 6.2, 95% CI 2.3– 16.6, P < 0.001) were independently associated with EV-A71 seropositivity in the Orang Asli population. Supply of clean drinking water may reduce the risk of EV-A71 infection. With significantly higher EV-A71 seropositive rates, younger rural children should be a priority target for future vaccination programs in Malaysia.

Item Type: Article
Uncontrolled Keywords: Hand, foot and mouth disease (HFMD), Enterovirus A71 (EV-A71), indigenous rural community (Orang Asli), high prevalence.
Subjects: Q Science > QR Microbiology
R Medicine > RZ Other systems of medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Gani
Date Deposited: 07 Jul 2023 02:56
Last Modified: 07 Jul 2023 02:56
URI: http://ir.unimas.my/id/eprint/42160

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