Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma

Emmanuella Nina Christina, Wakiman (2022) Bibliographic Analysis of p53-gene Family and Gene Expression Analysis of p53 in Nasopharyngeal Carcinoma. [Final Year Project Report] (Unpublished)

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Nasopharyngeal carcinoma (NPC) is relatively known as a unique malignancy associated with an oncovirus, Epstein-Barr virus (EBV), displaying genetic, epidemiological and regional distribution properties. Many researches have proved that p53 mutations are involved in NPC, but the precise gene expression of p53 is only partially understood. Identification on the dysregulation expression level of p53 in NPC can provide new insight into the future research and pathology of NPC by the discovery of a new prognostic marker. p53 is a tumor suppressor gene that most frequently mutated found in a large variety of human cancer epidemiology. In this study, bibliographical data was conducted fundamentally by Rstudio to study the publication and locality trend of p53 gene family from 2013 to 2022 across the world. As a whole, the data represents that the highest annual scientific production was on 2013, 7924 authors (87.41%) published 1 document each. With respect to citations, 2019 has the highest average article citations per year and the main country in terms of number of publications is China. The result clearly shows that USA is the most cited countries. On the other hand, for gene expression of p53 in NPC, the differential expression level of p53 between NP69 and HK1 are not able to be concluded since the intensity of GAPDH for NP69 and HK1 in Duplicate 1 are not the same. Besides, there is a band presence in GAPDH negative control.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2022.
Uncontrolled Keywords: p53, nasopharyngeal carcinoma, gene expression, bibliographic analysis
Subjects: Q Science > QL Zoology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Faculties, Institutes, Centres > Faculty of Resource Science and Technology
Depositing User: Dan
Date Deposited: 19 Sep 2022 05:01
Last Modified: 25 Jul 2023 08:14

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