Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls

Lynnette R., Ferguson and Isabel L, Fong and Amira E., Pearson and John, Ralph and Philip J., Harris (2003) Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 542 (1-2). pp. 49-58. ISSN 1383-5718

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We have determined the abilities of (E)-ferulic acid, (E)-p-coumaric acid and (E,E)-5-5-dehydrodiferulic acid to protect against different types of mutation in a simple bacterial model. These antimutagenic properties were compared with those of the related compound curcumin, and also with those of an extract containing hydroxycinnamic acids obtained by the saponification of the cell walls of wheat coleoptiles. Three known mutagens, bleomycin, hydrogen peroxide and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) were used to chemically induce reversion mutation, while the known antimutagen Trolox was used as a positive control. Both the pure hydroxycinnamic acids and the extract from the cell walls showed antimutagenic properties. It is known that hydroxycinnamic acids ester-linked to plant cell walls can be released in the human colon by the action of microbial esterases. Providing the current data extrapolate to mammalian cells, they suggest that antimutagenic properties of hydroxycinnamic acids released from plant cell walls could play a role in dietary fibre protection against cancer.

Item Type: Article
Uncontrolled Keywords: 5-5-Dehydrodiferulic acid; Antimutagen; Curcumin; Dietary fibre; Ferulic acid; Hydroxycinnamic acid; p-Coumaric acid; Salmonella
Subjects: Q Science > QR Microbiology
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Lim
Date Deposited: 25 Apr 2022 01:49
Last Modified: 25 Apr 2022 01:49

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