Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Samuel Ern Hung, Tsan and Marcucci, Maura and Painter, Thomas W. and Conen, David and Leslie, Kate and Lomivorotov, Vladimir and Sessler, David and Chan, Matthew T. V (2022) Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery. Trials, 23 (101). pp. 1-12. ISSN 1745-6215

[img] PDF (Main manuscript)
Marcucci 2022.pdf - Published Version

Download (1MB)
[img] PDF (List of investigators)
Marcucci 2022 Appendix 10.docx - Supplemental Material

Download (38kB)
Official URL: https://trialsjournal.biomedcentral.com/articles/1...

Abstract

Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e., most patients continue their antihypertensive medications throughout the perioperative period and intraoperative mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve perioperative outcomes.

Item Type: Article
Uncontrolled Keywords: Noncardiac surgery, Tranexamic acid, Perioperative bleeding, Perioperative hypotension, Cardiovascular. complications, Randomized controlled trial.
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Ern Hung
Date Deposited: 22 Apr 2022 02:54
Last Modified: 22 Apr 2022 02:54
URI: http://ir.unimas.my/id/eprint/38380

Actions (For repository members only: login required)

View Item View Item