Prophylactic topical tranexamic acid versus placebo in surgical patients: a systematic review and meta-analysis

Wan Yi, Teoh and Tun Giap, Tan and Ka Ting, Ng and Ke Xin, Ong and Xue Lin, Chan and Samuel Ern Hung, Tsan and Chew Yin, Wang (2021) Prophylactic topical tranexamic acid versus placebo in surgical patients: a systematic review and meta-analysis. Annals of Surgery, 273 (4). pp. 676-683.

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Abstract

Perioperative bleeding remains a major concern to all clinicians caring for perioperative patients. Due to the theoretical risk of thromboembolic events associated with tranexamic acid (TXA) when administered intravenously, topical route of TXA has been extensively studied, but its safety and efficacy profile remain unclear in the literature. The primary aim of this review was to assess the effect of topical TXA on incidence of blood transfusion and mortality in adults undergoing surgery.

Item Type: Article
Uncontrolled Keywords: meta-analysis, mortality, systematic review, topical agents, tranexamic acid, transfusion, UNIMAS, University, Borneo, Malaysia, Sarawak, Kuching, Sanarahan, IPTA, education, Universiti Malaysia Sarawak
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Ern Hung
Date Deposited: 08 Nov 2021 04:24
Last Modified: 08 Nov 2021 04:24
URI: http://ir.unimas.my/id/eprint/36632

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