A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

Hu, Ting Huey and Rosli, Nawal and Mohamad, Dayang Shuaishah Awang and Kadir, Khamisah Abdul and Ching, Zhen Hao and Chai, Yaw Hung and Ideris, Nur Naqibah and Ting, Linda S.C. and Dihom, Adeline A. and Kong, Sing Ling and Wong, Edmund K.Y. and Sia, Jenny Euk Huong and Ti, Tiana and Chai, Irene P.F. and Tang, Wei Yieng and Hii, King Ching and Divis, Paul Cliff Simon and Davis, T.M.E and Daneshvar, Cyrus and Singh, Balbir (2021) A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi. Scientific Reports, 11 (20117). pp. 1-11. ISSN 2045-2322

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Official URL: https://www.nature.com/articles/s41598-021-99644-8


Plasmodium knowlesi, a simian malaria parasite responsible for all recent indigenous cases of malaria in Malaysia, infects humans throughout Southeast Asia. There are two genetically distinct subpopulations of Plasmodium knowlesi in Malaysian Borneo, one associated with long-tailed macaques (termed cluster 1) and the other with pig-tailed macaques (cluster 2). A prospective study was conducted to determine whether there were any between-subpopulation differences in clinical and laboratory features, as well as in epidemiological characteristics. Over 2 years, 420 adults admitted to Kapit Hospital, Malaysian Borneo with knowlesi malaria were studied. Infections with each subpopulation resulted in mostly uncomplicated malaria. Severe disease was observed in 35/298 (11.7%) of single cluster 1 and 8/115 (7.0%) of single cluster 2 infections (p = 0.208). There was no clinically significant difference in outcome between the two subpopulations. Cluster 1 infections were more likely to be associated with peri-domestic activities while cluster 2 were associated with interior forest activities consistent with the preferred habitats of the respective macaque hosts. Infections with both P. knowlesi subpopulations cause a wide spectrum of disease including potentially life-threatening complications, with no implications for differential patient management.

Item Type: Article
Uncontrolled Keywords: UNIMAS, University, Borneo, Malaysia, Sarawak, Kuching, Samaraham, IPTA, education, Universiti Malaysia Sarawak
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Faculties, Institutes, Centres > Faculty of Medicine and Health Sciences
Depositing User: Simon Divis
Date Deposited: 03 Nov 2021 02:11
Last Modified: 03 Nov 2021 02:11
URI: http://ir.unimas.my/id/eprint/36547

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