One-pot and two-pot methods for chalcone derived pyrimidines synthesis and applications

Farooq, Saba and Zainab, Ngaini (2021) One-pot and two-pot methods for chalcone derived pyrimidines synthesis and applications. Journal of Heterocyclic Chemistry, 1 (1). pp. 1-16. ISSN 1943-5193

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Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.

Item Type: Article
Uncontrolled Keywords: pyrimidines, chalcone, present in ribonucleic acid (RNA), deoxyribonucleic acid (DNA), amino derivatives.
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Ngaini
Date Deposited: 26 Feb 2021 02:25
Last Modified: 26 Feb 2021 02:25

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