Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities

Chai, Tchan Wei (2014) Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities. [Final Year Project Report] (Unpublished)

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Abstract

A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E. Coli while compound 20 showed good activity against E. Coli.

Item Type: Final Year Project Report
Additional Information: Project Report (B.Sc.) -- Universiti Malaysia Sarawak, 2014.
Uncontrolled Keywords: Aspirin, Thiourea, Antibacterial activity, Escherichia Coil
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Unai
Date Deposited: 17 Feb 2021 08:06
Last Modified: 01 Oct 2021 10:33
URI: http://ir.unimas.my/id/eprint/34435

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