Drug Design :  Pharmacophore Modelling and Synthesis of Benzaldehyde Derivatives As Flies Repellent

Low, Jiin Yeu (2014) Drug Design :  Pharmacophore Modelling and Synthesis of Benzaldehyde Derivatives As Flies Repellent. [Final Year Project Report] (Unpublished)

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Abstract

Housefly (Musca domestica L.) is known as a vector of diseases to human. It can spread the various bacteria to the human through contaminated water source, poultry, animals, contaminated food and so on. Common diseases that caused by Musca domestica are typhoid fever, cholera, diarrhoeal disease and others. Because of the houseflies resistant to the insect repellents easily, thus it is necessary to synthesize new compound that can kill Musca domestica. By using pharmacophore modelling approach, the new lead compound can be discovered. The pharmacophore features include of hydrogen-bond acceptor (HBA), hydrophobic group (HY) or aromatic ring (AR) features. The benzaldehyde derivatives were synthesized via the Schiff base reaction. For the characterization of the synthesized compounds, NMR and FTIR and CHN analysis were used. The cytotoxicity test using brine shrimp, antioxidant activity test using DPPH and the biological repellent test using life flies were the validation test for the synthesized compounds. In this research, compound 3 and 13 are the best compounds as flies repellent based on the pharmacophore modelling and biological activity.

Item Type: Final Year Project Report
Additional Information: Project report (B.Sc.) -- Universiti Malaysia Sarawak, 2014.
Uncontrolled Keywords: Housefly, pharmacophore modeling, cytotoxity test, antioxidant activity test, biological repellent test
Subjects: Q Science > QD Chemistry
Divisions: Academic Faculties, Institutes and Centres > Faculty of Resource Science and Technology
Depositing User: Patrick
Date Deposited: 27 Jan 2021 07:01
Last Modified: 17 Jul 2021 13:45
URI: http://ir.unimas.my/id/eprint/34073

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