The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers

Han, Myitzu and Thwin, Mya Mya and Aung, Cho Lwin and Yi, Myat San and Yee, Khin Than and Mohd Nasir, Mat Nor and Bhagat, Vidya (2020) The Relationship between Serum Brain - Derived Neurotrophic Factor (BDNF) Level and Cognitive Function in Middle Aged Male Chronic Smokers. Research Journal of Pharmacy and Technology, 13 (10). pp. 4925-4930. ISSN 0974-360X

Full text not available from this repository. (Request a copy)
Official URL: https://rjptonline.org/HTMLPaper.aspx?Journal=Rese...

Abstract

Cigarette smoking is a pervasive high-risk behavior and recent studies reported that nicotine in tobacco influences a wide variety of cognitive domains. BDNF is one of the factors of the neurotrophin family that can regulate the cognitive functions of the brain. The purpose of this study is to assess the relationship between serum BDNF level and cognitive function in middle-aged (40-60years) male chronic smokers. The material used in the study, Brain-derived neurotrophic factor (BDNF) and General Memory Scale (GMS) to assay ELISA, and to test the cognitive function respectively. The results showed that serum BDNF level of chronic smokers (19.19±6.05ng/ml) was comparable with that of non-smokers (20.83±8.63ng/ml). The total GMS scores of chronic smokers (n=41) had significantly lowered total GMS scores (56.88±12.24) than that of non-smokers (n=41) (67.74±7.59) demonstrated cognitive functions. Although the cognitive function of chronic smokers was significantly lower than that of non-smokers, serum BDNF level of chronic smokers was not significantly different from non-smokers (p>0.05). Moreover, serum BDNF level was positively correlated with cognitive function (total GMS scores) in both chronic smokers’ group (r =0.453, p=0.003) and non-smokers group (r =0.458, p=0.003). The study results indicate, even in middle-age healthy adults, chronic smoking would impair cognitive function. The study concludes by portending the role of BDNF in cognitive function, whether or not the individuals are chronic smokers.

Item Type: Article
Uncontrolled Keywords: Cigarette smoking, Tobacco influences on cognition, Brain-derived neurotrophic factor, unimas, university, universiti, Borneo, Malaysia, Sarawak, Kuching, Samarahan, ipta, education, research, Universiti Malaysia Sarawak
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Faculties, Institutes and Centres > Faculty of Medicine and Health Sciences
Depositing User: Tuah
Date Deposited: 16 Oct 2020 01:22
Last Modified: 16 Oct 2020 01:22
URI: http://ir.unimas.my/id/eprint/32194

Actions (For repository members only: login required)

View Item View Item